Foster, MP
1992
The Revised Structure of Bistramide A (Bistratene A): Application of a New Program for the Automated Analysis of 2D INADEQUATE Spectra
Foster, M.P.; Mayne, C.L.; Dunkel, R.; Pugmire, R.J.; Grant, D.M.; Kornprobst, J.-M.; Verbist, J.-F.; Biard, J.-F. and Ireland, C.M.
Journal of the American Chemistry Society, 114(3):1110-1111, 1992. Funded by National Institutes of Health and US Department of Energy.
The two-dimensional structure of bistramide A (a.k.a. bistratene A) has been revised. The bis-amide polyether was isolated from a Lissoclinum sp. ascidian collected in the Fiji islands. The structure was established by a combination of modern NMR methods including 2D INADEQUATE, PS-DQF-COSY, HMQC and HMBC experiments. Critical to establishing the carbon-carbon backbone was CCBond, a new program for automated analysis of 2D INADEQUATE spectra. Bistramide A demonstrated in vitro cytotoxicity towards human colon tumor HCT-116 and murine leukemia L1210 cell lines with an IC50 of 0.1 µg/mL.
Applications of the Improved Computerized Analysis of 2D INADEQUATE Spectra
Dunkel, R.; Mayne, C.L.; Foster, M.P.; Ireland, C.M.; Li, D.; Owen, N.L.; Pugmire, R.J. and Grant, D.M.
Analytical Chemistry, 64:3150-3160, 1992. Funded by US Department of Energy, Pittsburgh Energy Technology Center and ACERC.
This paper illustrates the use of the program CCBond to determine the carbon skeletons of bioorganic molecules in low concentration samples. Discussed is the structure elucidation of bistramide A, a compound extracted from a Fijian Lissocllnum sp. and cholesterol in 71- and 20-µmol samples, respectively. The detection limit of the automated bond extraction is shown to be improved compared to the manual interpretation of 2D INADEQUATE spectra.
1991
The Revised Structure of Bistramide A (Bistratene A): Application of a New Program for the Automated Analysis of 2D INADEQUATE Spectra
Foster, M.P.; Mayne, C.L.; Dunkel, R.; Pugmire, R.J.; Grant, D.M.; Kornprobst, J.-M.; Verbist, J.-F.; Biard, J.-F. and Ireland, C.M.
Journal of the American Chemistry Society, 1991 (in press). Funded by National Institutes of Health and US Department of Energy.
The two-dimensional structure of bistramide A (a.k.a. bistratene A) has been revised. The bis-amide polyether was isolated from a Lissoclinum sp. ascidian collected in the Fiji islands. The structure was established by a combination of modern NMR methods including 2D INADEQUATE, PS-DQF-COSY, HMQC and HMBC experiments. Critical to establishing the carbon-carbon backbone was CCBond, a new program for automated analysis of 2D INADEQUATE spectra. Bistramide A demonstrated in vitro cytotoxicity towards human colon tumor HCT-116 and murine leukemia L1210 cell lines with an IC50 of 0.1 µg/mL.
Foster, MP
1992
The Revised Structure of Bistramide A (Bistratene A): Application of a New Program for the Automated Analysis of 2D INADEQUATE Spectra
Foster, M.P.; Mayne, C.L.; Dunkel, R.; Pugmire, R.J.; Grant, D.M.; Kornprobst, J.-M.; Verbist, J.-F.; Biard, J.-F. and Ireland, C.M.
Journal of the American Chemistry Society, 114(3):1110-1111, 1992. Funded by National Institutes of Health and US Department of Energy.
The two-dimensional structure of bistramide A (a.k.a. bistratene A) has been revised. The bis-amide polyether was isolated from a Lissoclinum sp. ascidian collected in the Fiji islands. The structure was established by a combination of modern NMR methods including 2D INADEQUATE, PS-DQF-COSY, HMQC and HMBC experiments. Critical to establishing the carbon-carbon backbone was CCBond, a new program for automated analysis of 2D INADEQUATE spectra. Bistramide A demonstrated in vitro cytotoxicity towards human colon tumor HCT-116 and murine leukemia L1210 cell lines with an IC50 of 0.1 µg/mL.
Applications of the Improved Computerized Analysis of 2D INADEQUATE Spectra
Dunkel, R.; Mayne, C.L.; Foster, M.P.; Ireland, C.M.; Li, D.; Owen, N.L.; Pugmire, R.J. and Grant, D.M.
Analytical Chemistry, 64:3150-3160, 1992. Funded by US Department of Energy, Pittsburgh Energy Technology Center and ACERC.
This paper illustrates the use of the program CCBond to determine the carbon skeletons of bioorganic molecules in low concentration samples. Discussed is the structure elucidation of bistramide A, a compound extracted from a Fijian Lissocllnum sp. and cholesterol in 71- and 20-µmol samples, respectively. The detection limit of the automated bond extraction is shown to be improved compared to the manual interpretation of 2D INADEQUATE spectra.
1991
The Revised Structure of Bistramide A (Bistratene A): Application of a New Program for the Automated Analysis of 2D INADEQUATE Spectra
Foster, M.P.; Mayne, C.L.; Dunkel, R.; Pugmire, R.J.; Grant, D.M.; Kornprobst, J.-M.; Verbist, J.-F.; Biard, J.-F. and Ireland, C.M.
Journal of the American Chemistry Society, 1991 (in press). Funded by National Institutes of Health and US Department of Energy.
The two-dimensional structure of bistramide A (a.k.a. bistratene A) has been revised. The bis-amide polyether was isolated from a Lissoclinum sp. ascidian collected in the Fiji islands. The structure was established by a combination of modern NMR methods including 2D INADEQUATE, PS-DQF-COSY, HMQC and HMBC experiments. Critical to establishing the carbon-carbon backbone was CCBond, a new program for automated analysis of 2D INADEQUATE spectra. Bistramide A demonstrated in vitro cytotoxicity towards human colon tumor HCT-116 and murine leukemia L1210 cell lines with an IC50 of 0.1 µg/mL.